Function: Replaces your attack with a swinging sword. After a few seconds a huge missile hits the target and deals 20x your tear damage to anything nearby, Essentially a one-time use of the Epic Fetus item, * item room, treasure room, item room pool, grey, gray, robot, Isaac's tears now have a piercing effect which allows them to travel through enemies instead of breaking on hit, * item room, treasure room, item room pool, arrow, penetrative, penetrating shots, grey, gray, You must make it back through the path solving a few bomb puzzles while avoiding her, to get back to the regular floor. I would understand if they would tune down normal mode tho, but leaving hard mode as it is presents a nice option for people who want a challenge. Poison, Homing, Prize Bombs), In Antibirth this was called Enigma Bombs, Spawns a red worm familiar that chases enemies nearby around the room and deals 2 contact damage per tick. Cursed gives a card that buys everything in a shop for free (or devil room) Waka Waka and the Host unlock some great items (scythe tears, and added laser to your tears without harming normal tears) Family Man unlocks epic fetus, which is way overpowered. This is shown by the Azazel skin spreading on Isaac's face, After 4 rooms, Isaac's face will flash red. If you have PhD it will only increase one stat, Can be used multiple times, but every time you use it, it has a chance to disappear, The Gold Pill can spawn as a Horse Pill, which then causes it to give random Horse pill effects, UNLOCK: Unlock this by defeating Mega Satan as Tainted Cain, Horse Pills rarely spawn as larger versions of normal pills with more powerful effects, Items that synergize with pills also have the same effect with Horse pills, In general, the effect of a Horse Pill is double the effect of a normal pill i.e. If used with Brimstone you have a 100% chance to fire a laser out the back of your head, * dungeon room, blood challenge room, arena pool, item room, treasure room, item room pool, Curse Rooms and Blood Donation Machines don't trigger this effect, Items with a price will spawn the extra item free of charge (i.e. Each secret room contains a beam of light, that gives half a soul heart, and a Tears Up for the rest of the floor. Upon use, this item summons a ghost near Isaac that will follow him around. He even has a slower rate of fire than the base stats. He won't respawn even if you move to a new floor, Will always match your current movement speed, UNLOCK: Unlock this item by defeating The Beast as Tainted Keeper, Only found in the Mausoleum/Gehenna II boss room, The item itself has no effect, but triggers the ascent through the backwards path towards the Home floor. Upon hitting the last button, this unlocks a Mine Cart, which is somewhere on the floor. Doesn't apply to progress items like The Polaroid, When you pick up an item that increases your maximum HP, you gain 2 permanent stat increases, and a temporary damage boost that slowly goes down over time. This tear turns enemies to gold for a few seconds and causes them to drop 1-4 coins if killed while golden (similar to the Midas' Touch item), When the Midas Touch tear effect triggers, it will remove 1 coin from your current total, The golden tear deals double your tear damage, The effect can still trigger even if you have no held coins, UNLOCK: Unlock this item by defeating Greedier Mode with Keeper, Doubles the effect of most tarot cards. This room will always drop a reward at the end, then allow you to exit back to the real floor, UNLOCK: Unlock this trinket by defeating The Beast as Tainted Cain, While held this trinket causes spikes to retract into the floor, Works for curse rooms - you no longer take damage entering or leaving, Allows you to open spiked chests without taking damage, Allows Planetariums to spawn in the Womb/Utero floors, Planetarium have a base 1% chance to appear, which increases by +20% whenever you skip an Item Room (Must not enter to count as skipped), After entering a Planetarium the chance goes back to 1%. Can be used with Placebo to generate infinite batteries, Amnesia - Hides the floor map for the rest of the current floor (same as curse of the lost). * secret room pool, item room, treasure room, item room pool, 25, grey, gray, silver, devil pool, devil room pool, devil deal, Converts most negative pills into their positive counterparts, e.g. . D6, D20 etc. Film & Animation; Autos & Vehicles; Music; Pets & Animals; Sports; . It can be anything including spawning a bunch of consumables, spawning a glitched pedestal item, creating a bunch of light beams, spawning troll bombs or nothing at all, UNLOCK: Unlock this item by defeating The Beast as Eden, "Isaac and his mother lived alone in a small house on a hill", When picked up, all future items become 'glitched', causing them to become random combinations of 2-3 effects based on other items, Glitched items can be passive or active and are completely randomly generated with infinite possibilities (similar to other 'Randomizer' games), The ratio of active to passive item effects given is 1/4, Random effects combine effects that exist on other items, and assign them to a random event (e.g. Based on the Steam Workshop mod created by Maddogs, UNLOCK: Unlock this item by picking up Rubber Cement 5 times, Spawns 3 red hearts on the ground when picked up, Added as part of the Afterbirth+ Booster Pack #5, UNLOCK: Unlock this item by defeating Mom's Heart on hard mode as The Forgotten, This item gives you an orbital, which will reflect projectiles back at enemies, Unlike some other orbitals, Slipped Rib doesn't deal contact damage to enemies, UNLOCK: Unlock this item by defeating the Isaac boss as The Forgotten, A familiar which follows Isaac and spawns a white poop when you take damage, The white poop gives an aura that cuts your tear delay in half (Tears up) and has a chance to block damage, The aura disappears if the poop is destroyed. *, parchment, quill, script, pact, feather, scroll, death list, deaths list, paper, contract, With Haemolacria, Isaac's tears become bloody and now fire by in the air in an arc, Upon hitting the floor, an obstacle or enemy, the bloody tear will burst and fire lots of smaller tears at random directions around the impact point, Your damage stat is unaffected by this item, however the large bloody tear does +31% of your tear damage and the smaller scattering tears deal 50-80% of your tear damage, Added as part of the Afterbirth+ Booster Pack #4. From the creative mind of Edmund McMillen came a dungeon crawler inspired by The Legend of Zelda, loaded with religious, astrological, pop culture, and toilet humor references. The damage done by Glass Cannon is calculated as follows: dmg = (dmg * 10) + 10 (i.e. shop item pool, brown, x, cross, paper, Isaac has a random chance to fire another tear out the back of his head, The chance to fire the second tear can improve based on your luck stat and will always activate at +5 Luck, At +0 luck theres a ~50% chance for this effect to activate, Synergizes very well with a lot of items. Function: Pay 5 cents for a 25% chance to win up to 3 items from the Crane Game pool, Unlock Condition: Defeat Mega Satan as Tainted Samson. Doesn't include Curse Room doors or spiked rocks, Tears can be controlled mid-flight using the directional keys, In addition to regular tears, Isaac will sometimes fire extra spectral tears that orbit around him, Fully heals all your red heart containers, Isaac now emits a large light aura that damages nearby enemies 5 times per second while touching it, The visual effect is similar to the effect given to tears by the GodHead item, The aura deals more damage towards the center, ranging from 0.75 at max range to 4 damage when touching Isaac, In addition to normal tears, Isaac now also fires a set of 4 quadshot tears with a slowing effect, The quadshot tears deal 1.5 damage each and do not scale with your damage upgrades, Upon taking damage, you have a chance to dislodge the spider from your face. ), UNLOCK: Unlock this item by beating Blue Womb (Hush) with Cain, Gives Isaac a familiar golden Censer which creates a huge aura of light that slows down any enemies inside it, UNLOCK: Unlock this item by beating Greed Mode with Maggy, A familiar beggar similar to Bum Friend that follows Isaac and collects keys, giving random chests in return, UNLOCK: Unlock this item by beating Greed Mode with Lazarus, Item Pool: Item Room, Secret Room, Key Beggar, *, grey, gray, black, face, stone, rock, baby, A bag that follows Isaac and drops a random Rune or Soul Stone every 7 or 8 rooms, UNLOCK: Unlock this item by beating the Isaac boss with Lilith, A familiar angel which follows Isaac and fires Sacred Heart tears which deal 10 damage at -25% shot speed and a reduced fire rate, Item Pool: Item Room, Angel Room, Greed Mode Angel Room, This item causes enemy projectiles to be able to hit other enemies. ?s soul, blue baby's soul, blue babys soul, When you kill an enemy, you have a chance to get +0.5 damage up for the current room, UNLOCK: Unlock this item by beating the Dark Room with Samson, *, hair, pony, tail, brown, red, samsons lock, Gives a 25% chance to reveal map icons at the start of a new floor (The same effect as the Compass), UNLOCK: Unlock this item by beating the Chest with Cain, When you kill an enemy, you have a chance to spawn a transparent Dead Bird familiar, The Dead Bird familiar deals 2 damage per tick to enemies while in contact with them, UNLOCK: Unlock this item by beating the Isaac boss with Eve, *, grey, gray, black, striped, eves bird foot, REPENTANCE - No longer replaces chests that have already spawned, UNLOCK: Unlock this item by beating Ultra Pride, * northernlion, drop the left hand, paw, bloody, bleeding, grey, gray, While held, tinted rocks and rocks with a crawlspace below them will flash white every 10 seconds, *, grey, gray, silver, lump, metal, stone, Turns all troll bombs into bombs which you can pick up and use, Super Troll bombs turn into 1+1 free double bomb pickups, Gives your tears a random worm effect every few seconds, The possible tear effects include: Whip Worm, Ring Worm, Wiggle Worm, Flat Worm, Hook Worm, Pulse Worm, Tape Worm and Lazy Worm, While held, Tape Worm doubles your range stat and halves your tear height stat, Every time you get hit, you have a chance to activate the D6, D20, D8, D10 or D12 effect. It returns after a room has been cleared, UNLOCK: Unlock this item by beating Greed Mode with Eden, Item Pool: Item Room, Secret Room, Greed Mode Shop, *, red, yellow, green, white, square, rectangle, When used, the D8 rerolls all of your stats, Will only effect your damage, tears, range and speed stats, Each stat is given a multiplier that applies after all other adjustments, UNLOCK: Unlock this item by beating Challenge #28 (Pride Day), * dice, pip, die, black, grey, gray, pyramid, triangle, Purity will boost one of Isaac's stats depending on the colour of the aura around him, When you take damage, the aura will be removed and replaced with another random one when you enter the next room, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Maggy, Item Pool: Item Room, Angel Room, Greed Mode Item Room, Greed Mode Angel Room, Adds a chance for a black ring to spawn around killed enemies, dealing damage to others that touch it, The ring damage scales with your tear damage, The change for a ring to spawn scales with your lucky stat, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Eve, Item Pool: Devil Room, Curse Room, Greed Mode Devil Room, *, grey, gray, silver, metal grabber, hand, robot, When Isaac has no red hearts, this item gives Isaac the ability to fly. * arcade, skull game, black, heart, pink, love, Gives Isaac 2 orbital flies which block enemy shots, Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies, * item room, treasure room, item room pool, key master pool, key beggar pool, key judgement pool, two, flies, black, When revived, the green mushroom that follows Isaac will disappear and he will respawn with the same amount of red heart containers at full health, Resurrection takes place before all other items which give you an extra life, * secret room pool, mario, green mushroom, extra life, spots, spotted, x1.5 times Damage Multiplier (Does not stack with the multipliers from Cricket's Head / Blood of The Martyr + Book of Belial), Increases the size of your player sprite, but doesn't increase the hitbox, Counts as 1 of 3 mushroom items needed towards the Fun Guy transformation, Counts as 1 of 3 size-increasing items needed towards the Stompy transformation, * boss room pool, boss room item, item room, treasure room, item room pool, red, spots, spotted, amanita muscaria, Enemies touching you take 12 damage, then a poison effect is applied for 6-7 ticks, dealing damage equal to the amount of red hearts you have (up to 30.8 at 12 full red hearts), Has a chance to drop from the Lust miniboss fight, Counts as 1 of 3 syringe items needed towards the Spun transformation. the ability to fly. See previous icon for normal character effects, Tainted Isaac - Adds 4 more spaces for passive items, Tainted Maggy - Adds 1 extra real heart container that doesn't deplete, Tainted Cain - Doubles picks dropped when touching an item, Tainted Judas - Increases the range in which Dark Arts hits enemies and tears, Tainted ??? Gives a one-time use of the D6 and D20 effects at the same time, When used will cause two of Mom's Hand to come down and grab a random enemy, Grants the Holy Mantle effect for, which will negate your next hit of damage, Tainted Lost starts with this card, and while playing as this character all cards and runes have a 10% chance to turn into a Holy Card, UNLOCK: Unlock this item by defeating Delirium in The Void floor with The Lost. Changed to 2 room recharge, * golden chest pool, gold chest pool, item room, treasure room, item room pool, bob sloth, jailbird paper washington, nc; axe throwing augusta maine; eric pospisil age; david dayan fisher binding of isaac: repentance unlock guide. This is the strongest Shop item in the entire game. The floor generation can fail and cause the guaranteed Planetarium to not spawn sometimes. Following the path takes you to an abandoned mineshaft, which leads you to a pedestal with the Knife Piece. Glitched Crown is in this list as the strongest among them once you learn how to pick out the item you want consistently. Items picked up are not shared between the two characters, UNLOCK: Unlock this item by defeating The Beast as Tainted Jacob, When activated, Isaac's tears are replaced by a bone sword and he goes on a killing rampage, gaining +0.4 Speed, +3 Flat Damage Up for 5 seconds, The sword deals x3 damage if used at close range, or x1.5 damage if charged up and thrown, Clearing rooms doesn't charge this item - charge is added equal to damage taken by enemies. pants, under wear, pink, knickers, moms underwear, mom underwear, REPENTANCE - Touching enemies deals 12 damage to them, Item Pool: Boss Room, Challenge Room, Mom's Chest, * dungeon room, blood challenge room, arena pool, boss room pool, boss room item, red, high, shoe, moms heels, mom heels, Drops a random heart on the floor when picked up, * moms lipstick, mom lipstick, dungeon room, blood challenge room, arena pool, boss room pool, boss room item, red, grey, gray, UNLOCK: Unlock this item by beating Mom's Heart 4 times, Gives Isaac angel wings for the current room, allowing him to fly, Instantly kills the Mom's Foot, Mom's Heart and It Lives boss fights, If used during the Satan fight, The Bible will instantly kill Isaac, Counts as 1 of 3 angel items needed towards the Seraphim transformation, REPENTANCE - Reduced to 4 room recharge time, * library pool, library room, book room pool, angel room pool, god room pool, angel room item, The spear occasionally inflicts fear on enemies it damages. Releasing Dark Esau will cause him to charge directly at Jacob and deal damage to anything in his path. The locust fly will do different things for each harbinger - e.g. This item is also extra strong in Ascension runs and Greed Mode runs. Reveals the location of one secret room on the minimap. Bethany - Activating an item using soul charges is sometimes free, Jacob & Esau - The character who picks up Birthright gains copies of three of the other character's passive items, UNLOCK: Unlock this item by defeating ??? Stealing an item has a chance to fail (a buzzer sound will play if it fails), Enemies: Attacks the enemy until either the ghost or the enemy dies, Doors: Opens the door, even if it is locked, Secret room entrances: Explodes and opens the entrance, Boss rush door: Will open the Boss Rush door from either side, allowing you get into and escape the Boss Rush, Slot machines, dead shopkeepers: Charges towards them and explodes them, Added as part of the Afterbirth+ Booster Pack #3. Spoilers of course for Repentance mechanics and unlock conditions. the lost item pool, white, blue, cross, jar, Gives Isaac an eternal heart and the ability to fly, UNLOCK: Unlock this item by beating the Chest with Blue Baby, * golden chest pool, gold chest pool, blue head, the lost item pool, dead, ball, Upon taking damage, Isaac will fart a few times, causing all enemies in close proximity to become poisoned and leaving a gas cloud behind, Black Bean deals your tear damage for 6 ticks, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, item room, treasure room, item room pool, the lost item pool, kidney, grey, gray, Allows Isaac to fly while the White Pony is held, While held, sets your speed stat to 1.5 if it isn't already that high. * item room, treasure room, item room pool, dungeon room, blood challenge room, arena pool, A familiar that follows Isaac and charges forwards very slowly, dealing 2.7 damage per tick to any enemies it comes into contact with, Almost identical to the Little Chubby familiar, but this one moves much more slowly and deals less damage, REPENTANCE - The damage tick rate on Big Chubby has been increased, Upon use, this item deals 9,999,999 damage to all enemies in the room and then kills you 3 seconds later, This is a single use active item, meaning it is destroyed after using it, Does not kill both phases of multi-phase bosses like Hush or Ultra Greed, If used to kill a boss, the kill still counts as a victory for post-it note completion marks, but the run will still get a game over, Delirium's death animation takes longer than 3 seconds, meaning you will die before it can count as a completion mark. Want to play with item revealing mods and still unlock unlocks. In Afterbirth+, taking 3 of this pill gives the Adult transformation, Pretty Fly - Gives Isaac +1 fly orbital, which blocks enemy projectiles and damages fly-type enemies on touch, Range Down - Reduces your range stat by -2, Range Up - Increases your range stat by +2.5, R U a wizard? effect for the floor, UNLOCK: Unlock this item by beating Satan with Eden, Item Pool: Item Room, Library, Secret Room, * library pool, library room, book room pool, secret room pool, item room, treasure room, Cain - +1 Luck. Holding this trinket increase that chance by +15%. Commenting just for future use. Stat Down pills do nothing, and items like Experimental Treatment increase stats but don't reduce any, This effect works on items that apply negative stat modifiers, such as Soy Milk, This effect works for anything that gives temporary buffs, like Devil/Strength cards, or kill bonuses like Bloody Lust, If you somehow lose Rock Bottom, your stats will go back to normal, UNLOCK: Unlock this item by defeating the Boss Rush as Jacob & Esau, Bombs now explode with a random effect (e.g. box, yellow, grey, When used, converts 1 soul/black heart into 1 red heart container, This item will take from your soul hearts first, REPENTANCE - Converter now only costs one soul heart to use (previously costed two), * shop room pool, shop item pool, the lost item pool, blue, gray, grey, yellow, sprocket, When used, this item will spawn a set of items or consumables based on which chapter you are currently on, Basement 1: 2 Soul hearts. No longer drops black hearts like it used to. Im not really at the point where i need them yet, but if anyone reading this knows somewhere i should look, hit me up, This is super helpful. There are some 300 gameplay changes, according to YouTuber IsaacGuru. If the enemy dies while in this state they will drop 1-4 coins, Rainbow poop Dips charm enemies and have a chance to spawn 1/2 a red heart on death. Pills with effects that can't necessarily 'double' are stronger, i.e. 's unique poops, Corn poop - Spawns a blue fly every 2 seconds, Flaming poop - Leaves behind fire that damages enemies, Black poop - Creates slowing black creep. are both top tier unlocks! when entering the item room, Gives +1 Soul Heart when starting each new floor after picking this up, Currently this effect doesn't work in Greed Mode - It will show 2 items but the item rooms will have different items in them, Gives +0.4 Tears Up for each room completed without taking damage, up to a maximum of +2.0 Tears Up, When you take damage, the tears bonus is reset, Picking this item up counts and gives you a temporary +0.4 Tears Up as well, Allows you to double-tap the shoot button to create a holy shield for 1 second that pushes enemies back and deals 10 damage to them if they touch it, The shield also reflects enemy shots and beams back at them for some extra damage, Can only be activated every 3 seconds (Shown by a white glow and a ticking noise). white, brown, underwear, moms bra, mom bra, Causes an explosion near Isaac which takes away half a heart and does 40 damage all enemies in close proximity, REPENTANCE - Kamikaze now has increased blast damage and radius. Donation machines become fixed if they were jammed before using the R Key, Isaac now has a chance to fire a fist instead of normal tears, which have a much higher knockback effect and confuse enemies for a few seconds, Enemies that are knocked back will take 10 damage and knock back any enemy they are knocked into, dealing damage to them as well, An active item that allows you to throw an eraser at any enemy, which will kill it and prevent it from appearing for the rest of the run, Enemies that are erased create a puff of smoke instead of spawning, Works on bosses, except it doesn't kill them it just deals 15 damage, Can only be used once per floor - batteries also cannot be used to recharge it to bypass this restriction, The first use will raise it above your head, then by pressing the fire button it will be thrown in that direction, Recharge time: 1 room (Can only be used once per floor), When used, this item will give you +1 Rotten Heart, Rotten Hearts act as red hearts and each one you currently have spawns 2 blue flies upon successfully clearing a room, UNLOCK: Unlock this item by defeating Mother in the Corpse II as Maggy, Enemies now create a soul upon death, which is automatically sucked into the Urn giving it +1 charge. REPENTANCE - Dark Prince's Crown now grants more of an increase in rate of fire, and the bonus now breaks the soft tears cap. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. Tech.5/Technology Zero/Jacobs Ladder: The extra damage is very helpful. Posted on . Lovers? Boosts speed, range, shot speed, tears and damage if they are above their base values by roughly +20%, Affects stat bonuses from passive items, trinkets that are absorbed or in a second trinket slot, and permanent bonuses given by items such as Void, UNLOCK: Unlock this trinket by getting a 5-win streak in daily challenges (must have a score of above 0 on the score screen), While held, gives the Skatole effect only in certain rooms, which will turn hostile flies to neutral and stop others from shooting, Attack, Dart and Ring Flies turn into neutral Black Flies and Pooters and Fat Flies will no longer fire at you, Items and trinkets which generate blue flies and spiders will have double the effect, causing twice as many to spawn, *, grey, gray, green, arrow, flower, plant, Some tears will randomly become a black tooth, that deal double your normal tear damage and can poison enemies, Tears become spectral and travel in a huge spiral pattern, Every time you take damage you have a very small chance to gain a Tonsil familiar, which follows you and blocks enemy projectiles, This effect can happen twice before the Tonsil trinket is destroyed, Your tears have a random chance to become booger tears, Booger tears stick on to enemies and deal periodic poison damage until they die or 60 seconds passes. You may take only one of the items, before being teleported back to where you were, It's literally every item, that includes items not in item pools like Knife Pieces, UNLOCK: Unlock this item by completing every post-it note for every character, including the Tainted characters, Gives you a robot fly familar that orbits around Isaac and fires shielded tears at incoming projectiles, Deals contact damage to enemies it touches, Counts as 1 of 3 fly items needed towards the Beelzebub transformation, Item Pool: Item Room, Key Beggar, Crane Game, When used, the Meat Cleaver will split all enemies in the room into 2 smaller versions with ~40% health each, For enemies that have multiple parts to them (e.g. They also retain most of your bomb synergizing items, This item causes your bombs to stick to enemies and when exploding will leave white creep on the ground which slows enemies, When one of your bombs kills an enemy, a bunch of blue spiders are spawned to fight by your side, which deal x2 your current damage, Item Pool: Item Room, Greed Mode Item Room, Bomb Beggar, Bomb Beggar, Shooting in one direction increases your fire rate until a cap is reached, The maximum effect is to halve your delay, which takes roughly 10 seconds to achieve, The accuracy of your tears is also reduced as your fire rate increases, As soon as you change firing direction, your fire rate is reset to its normal amount, Tears will now travel through walls and appear out of the opposite wall, similar to a portal-type mechanic, Your tears can now also travel over rocks and objects in the environment, Spawns 3 random types of hearts on the floor, *, pink, blonde, yellow, red, bow, baby mr dolly, Causes Isaac to spawn 6 troll bombs on the floor every time he gets hit, similar to the Anarchist Cookbook mechanic, Doesn't trigger on damage taken from blood donation machines and devil beggars (but still triggers on other forms of intentional self damage such as IV Bag), Item Pool: Item Room, Red Chest, Curse Room, Greed Mode Item Room, *, blue, orange, poster, torn, paper, page, ripped, A familiar baby that has a random chance to drop a battery pickup or freeze all enemies in the room for a short while, Charged Baby also has a chance to add one charge to your spacebar item, These effects can only occur while in a hostile room with enemies, Gives Isaac a +25% damage up for every tear that successfully hits an enemy, The bonus from Dead Eye maxes out at double your damage (+100%), If a tear misses an enemy, there is a chance for the multiplier to be reset back to 1. 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